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End-stage liver disease

Introduction

End-stage liver disease (ESLD) covers a wide spectrum of pathologies, including:

  • acute liver failure without underlying chronic liver disease (ALF),
  • compensated advanced chronic liver disease (cACLD) and
  • decompensated cirrhosis,
    the latter may be chronic decompensation (CD) or acute decompensation (AD) with or without organ failure (acute on chronic liver failure, ACLF). In this context, bacterial infection is the most frequent trigger for acute decompensation and ACLF, and a frequent secondary complication in these patients.

Objectives

The research area aims to improve :

  • the identification of patients with end-stage liver disease (ESLD) who are at greatest risk of worsening their disease,
  • the diagnosis and prognosis of bacterial infections in ESLD, and
  • the diagnostic and prognostic stratification of patients with ESLD.

Strategy

Projects

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Publications

2023 Jul -

iScience

PMID : 37575179

Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis

Chouik et al.

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Centre intégré des maladies du foie
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Institut d’hépatologie de Lyon, 2023