Liver transplantation

Introduction

In the context of a growing increase in chronic diseases and liver cancer, liver surgery and transplantation represent a major curative therapeutic option. Because of the severity of the underlying liver disease, surgical care remains difficult and not all patients registered for transplantation are able to receive a liver transplant.

Optimising the conditions of access to transplantation and surgical techniques is a major challenge for patients with severe liver disease.

Objectives

  • To develop new predictive models for prioritising patients on the waiting list for a liver transplant.
  • To study the mechanisms underlying the two major postoperative liver injuries: ischaemia-reperfusion injury and haemodynamic dysfunction.
  • To identify biomarkers for predicting the severity and outcome of these complications.
  • Evaluate treatment strategies to mitigate these lesions and improve short- and long-term outcomes for patients.
  • Develop new methods for optimising and preserving liver grafts to improve patient access to transplantation and transplant outcomes.

Strategy

Projects

Publications

2018 Jun -

J Hepatol

PMID : 29410287

No-touch multibipolar radiofrequency ablation vs. surgical resection for solitary hepatocellular carcinoma ranging from 2 to 5 cm

Mohkam et al.

2020 May -

New England J Med

PMID : 32402160

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

Finn RS et al.

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